Hollander Combination Prolonged-Release Naltrexone/Bupropion Causes Significant Weight Loss Without Worsening Psychiatric Symptoms Authors: A. Halseth, P. Klassen, S. Klein About CONTRAVE CONTRAVE, approved by the United States Food and Drug Administration in September 2014, is indicated for use as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus or dyslipidemia). The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood. CONTRAVE has two components: naltrexone, an opioid antagonist, and bupropion, a relatively weak inhibitor of the neuronal reuptake of dopamine and norepinephrine. Nonclinical studies suggest that naltrexone and bupropion have effects on two separate areas of the brain involved in the regulation of food intake: the hypothalamus (appetite regulatory center) and the mesolimbic dopamine circuit (reward system). Four 56-week multicenter, double-blind, placebo-controlled Phase 3 clinical trials were conducted to evaluate the effect of CONTRAVE in conjunction with lifestyle modification in 4,536 subjects randomized to CONTRAVE or placebo. In these studies, the most common adverse reactions (>5 percent) seen in patients taking CONTRAVE included nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea. Important Safety Information WARNING: SUICIDAL THOUGHTS AND BEHAVIORS; AND NEUROPSYCHIATRIC REACTIONS Suicidality and Antidepressant Drugs CONTRAVE is not approved for use in the treatment of major depressive disorder or other psychiatric disorders.
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Elton John: The Rock-Pop icon in his recent past suffered from bulimia and other problems of drug abuse and alcoholism till he decided to go to a rehab canter. Fatigue, recurrent headaches, muscle aches, numbness of hands and feet, rashes, hot flashes and inability to control the anxiety are some of the common symptoms of this mental disorder Panic Disorder: A type of anxiety disorder that affects both adults and children, panic disorders lead to several, recurrent panic attacks. You feel that you need to self-inflict means of punishment for the act of binging. After an illness, some people live in the fear that certain foods will make them ill, so they begin to avoid them little by little. It is also known as the body salt imbalance or the body chemical imbalance. Even though now the emphasis is on a healthy body weight, and in fact skinny models have been rejected in several fashion shows, there is still a huge craze to be slim and skinny. A combination of various therapies such as nutritional therapy, counselling, cognitive therapy, family therapy and group therapy is used to treat this disorder. Do not ignore the desire to eat a particular food item, since it is better to eat something than nothing. Infertility: Women may not be able to give birth, if they are found to be deficient in luteinizing and follicle stimulating hormone. Specific Phobia: Derived from the Greek word photos, phobia is a feeling of intense fear of a specific thing that may or may not pose a danger to the person suffering from the fear.
Here are some of the eating disorders that are commonly observed: Anorexia: Anorexia nervosa is a psychological disorder, which is characterized by distorted perceptions of the body image and persistent fear of weight gain, which results in self-starvation and an extreme weight loss. Some people, by nature, have a short temper. Pyromania: Pyromania is an impulse control disorder wherein a person feels the uncontrollable urge to set fire. These diabetes is of many types, it could be due to lack of insulin in the body type 1 diabetes or due to development of tolerance to the action of insulin type 2 diabetes or may even be seen only during pregnancy gestational diabetes. In women the occurrence may hardly come as a surprise any more with the pronounced… This can be done by making certain lifestyle-related changes. Here are some of its psychological side effects. One amongst the depression medication list is Doxepin, which is sold under the brand name of atonal. It can cause significant distress in the life of a person and impair the functioning of a person in social or occupational settings. Note: Loss of appetite in the first trimester of pregnancy is a common phenomenon.
